MRIs expected on Monday for Adrian Peterson, Ray Edwards
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Both players left Sunday's 17-13 win over the Washington Redskins in the second quarter and did not return, although they returned to the bench after halftime with their helmets and full pads.
Peterson said the ankle "started to throb a little bit" shortly after he "got rolled up" at the end of a run with about 10 minutes remaining in the half. Trainers retaped the ankle twice, but neither that nor all the stretches Peterson did on the sideline made a difference.
"I would have tried to go out there," said Peterson, who was off to a fast start with 70 combined yards on seven touches.
"Trust me, if I could have went, I would have been out there. But it was just unbearable."
Edwards said he believed teammate Kevin Williams rolled into the back of one of his legs on a pass rush in the final minute of the half.
"It felt good walking on it, but running on it, I couldn't get my same explosion off of it," Edwards said, adding that he expects he'll "be all right."
Interim coach Leslie Frazier was vague about both injuries, saying only that the team "will know more tomorrow."
Both players' replacements fared well. Rookie halfback Toby Gerhart had 76 rushing yards and his first career touchdown, while Brian Robison sacked Redskins quarterback Donovan McNabb once and hit him on another play.
Another starter, safety Husain Abdullah, left the game briefly with what appeared to be another ankle injury but was back on the next series.